主要承担项目及成果 |
1.承担项目 主持必赢电子游戏网站人才科研启动项目1项;参与国家自然基金及重大专项等项目多项,部分项目如下: [1] 必赢电子游戏网站人才科研启动项目:食源性致病微生物的代谢组学研究及食品中有毒物质的形成,15万 [2] 国家自然科学基金委重点项目:生命早期镉暴露协同维生素D缺乏引发个体肠道菌群紊乱导致代谢异常的机制及干预研究,275万 [3] 国家自然科学基金面上项目:纳米二氧化钛长期低剂量膳食摄入诱发肠道菌群紊乱进而导致免疫功能异常的机制研究调控机制研究,60万 2.论文/论著 先后发表SCI 学术论文十余篇,申请专利5项,。部分论文及专利如下: [1] Wahl A#, Gralinski LE#, Johnson CE, Yao W, et al and Garcia JV*. SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801. Nature. 2021 Mar,591(7850):451-457. [2] Yang Y, Sun M, Yao W, et al and Yang C*, Ba Q*, Wang H*. Compound kushen injection relieves tumor-associated macrophage-mediated immunosuppression through TNFR1 and sensitizes hepatocellular carcinoma to sorafenib. J Immunother Cancer. 2020 Mar,8(1):e000317. [3] Li Xiaoguang, Yao Wenbo, et al and Wang Hui*, Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma , Gut, 2017, 66(1): 157-167. [4] Yao Wenbo, Ba Qian, Li Xiaoguang, Li Huiliang, Zhang Shoude, Yuan Ya, Wang Feng, Duan Xiaohua, Li Jingquan, Zhang Weidong*, Wang Hui*, A Natural CCR2 Antagonist Relieves Tumor-associated Macrophage-mediated Immunosuppression to Produce a Therapeutic Effect for Liver Cancer , EBioMedicine, 2017, 22: 58-67. [5] Yao Wenbo, Wang Feng, Wang Hui*, Immunomodulation of artemisinin and its derivatives , Science Bulletin, 2016, 61(18): 1399-1406. 3.专利 [1] Wenbo Yao, Guaiping Qiao, Juan Li, Nan Hui, Qiao ZENG, Han Li, Bin Tian, Yongbo Wang, Dan Yang, Jingwen Xu, Liang Qi, Yanjun Li, Chengyuan Liang*,Hydroxytyrosol ursodeoxycholic acid ester with antioxidant activity and a method of preparing the same,2020-4-9,美国,US10738077B1. [2]王慧*, 张卫东*, 姚文博, 李晓光, 一种新型的CCR2拮抗剂及其用途, 2016-03-23, 中国, CN201610168172.9. |